3 monkeypox sub-clusters found in India: ICMR study


Indian Council of Medical Research

has found three sub-clusters of monkeypox cases detected in India — first cluster of Kerala (n5) and Delhi (n2) is aligned with the USA-2022 ON674051.1; second cluster of Delhi (n3) is aligned with USA-2022 ON675438.1; and third which consists of the UK, US and Thailand.

According to the


study, all the retrieved monkeypox virus (MPXV) sequences from India covering 90% to 99% of the genome belong to the A.2 lineage of clade IIb.

During July-August 2022, clinical specimens i.e., oropharyngeal swab (OPS), nasopharyngeal swab (


), lesion crust and lesion fluids of 96 suspected monkeypox cases were referred from 18 states and three Union Territories to

ICMR-National Institute of Virology, Pune

, for diagnosis.

The 10 monkeypox confirmed cases were — three males and two females from New Delhi with no international travel history; five males were from Kerala with travel history from UAE to India.

All the cases were immuno-competent with no comorbidities with their mean age 31 years and presented with short prodromal phase of


, myalgia, vesiculo-pustular lesions primarily in genital area, face, trunk and extremities.

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